How Your Emotions Affect Your Body’s Immune Response

The Connection Between Mood, Emotions and Immunity

Your mental health and emotional well-being play a crucial role in your overall health. A growing body of research suggests that your emotions profoundly impact your body’s immune response, and vice versa. An imbalanced or suppressed immune system can significantly influence a person’s mood and behavior.1

The field of psychoneuroimmunology explores the intricate communication between the brain, nervous, endocrine, and immune systems. This interdisciplinary science examines how these systems interact and influence each other, impacting both physical health and emotional well-being. By understanding these connections, researchers aim to uncover how stress, emotions, and psychological states can directly affect immune function and overall health.2

How Positive and Negative Emotions Impact Immunity

Although researchers are still working to fully understand the complexities behind these interactions, the evidence is clear: positive emotions can boost immunity, while negative emotions can suppress it.

For instance, anxious thoughts can diminish your immune response within just 30 minutes, and persistent stress can damage your body's natural defense system, making you more susceptible to illness. Meanwhile, engaging in meaningful social interactions can reduce stress and promote a healthy immune response. 3,4,5

When you experience an emotion, your immune system immediately registers the change and responds. For example, laughter can instantly alter the number and function of immune cells circulating throughout your body. Similarly, emotions like crying and anger also prompt immediate immune responses.6

  • Positive emotions, such as happiness and joy, trigger the release of endorphins, which can enhance immune function. Endorphins are known to reduce stress and inflammation, promoting a more balanced immune response.
  • Negative emotions, such as sadness and anger, trigger the release of stress hormones like cortisol, which can suppress immune function. Elevated cortisol levels are known to increase inflammation and weaken the body's immune response.7

Practices such as mindfulness meditation and yoga can reduce stress, lower cortisol levels, and enhance immune function by increasing the activity of key immune cells. By reducing stress, you also help combat inflammation, supporting overall health, well-being, and a balanced immune system8

How Your Mood Affects Your Immune System

While emotions are intense and short-lived, creating immediate physiological changes in the body, moods are generally longer-lasting and less intense, often shaping our overall mental state and influencing our perceptions and behaviors over an extended period.

That said, your mood can have a profound effect on your immune system through various mechanisms, particularly those involving prolonged stress and its physiological impacts. While negative emotions can increase the production of stress hormones, chronic stress can lead to persistent inflammation in the body, which can weaken the immune system's ability to respond effectively9

Your mood can also influence your behavior, which in turn affects your immune health. For instance, people experiencing positive moods are more likely to engage in healthy behaviors such as exercising, eating nutritious foods, and getting adequate sleep—all of which support a strong immune system. Conversely, negative moods can lead to unhealthy behaviors like poor diet, lack of exercise, and insufficient sleep, further compromising immune function.

Strategies to Improve Your Emotional Health for Stronger Immunity

  1. Mind-Body Practices: As mentioned above, practices such as mindfulness meditation, yoga, and tai chi have been shown to reduce stress and help regulate cortisol levels, improving mood and immune function.8
  2. Physical Activity: Regular exercise is beneficial for both mental health and immune function, reducing inflammation, boosting mood through the release of endorphins, and enhancing immune cell activity.10,11
  3. Adequate Sleep: Quality sleep is essential for both mental and immune health. Poor sleep can lead to increased stress and inflammation, weakening the immune system. Establishing a regular sleep routine can help maintain a robust immune response. 12
  4. Health Diet: A balanced diet rich in antioxidants, vitamins, and minerals supports both mental and immune health. Foods high in omega-3 fatty acids, such as fish, nuts, and seeds, have anti-inflammatory properties that benefit both the brain and the immune system.13
  5. Social Connections: Strong social support networks can buffer against stress and improve mental health, positively influencing immune function. Engaging in meaningful social interactions can reduce stress and promote a healthy immune response.5

The intricate connection between mood, emotions, and immunity underscores the importance of a holistic approach to our overall health. Addressing your mental health through stress management, physical activity, proper nutrition, and social support can significantly enhance immune function.

Furthermore, supporting your immune system with a daily postbiotic, such as IMMUSETM, has been shown to promote year-round health. IMMUSE proactively supports your immune health, preparing your immune system to protect your health at a moment’s notice.*



Learn More About IMMUSE Postbiotic



1Brod S, Rattazzi L, Piras G, D'Acquisto F. 'As above, so below' examining the interplay between emotion and the immune system. Immunology. 2014 Nov;143(3):311-8.

2Tausk F, Elenkov I, Moynihan J. Psychoneuroimmunology. Dermatol Ther. 2008 Jan-Feb;21(1):22-31.

3Segerstrom SC, Miller GE. Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychol Bull. 2004 Jul;130(4):601-30.

4Vasile C. Mental health and immunity (Review). Exp Ther Med. 2020 Dec;20(6):211.

5Umberson D, Montez JK. Social relationships and health: a flashpoint for health policy. J Health Soc Behav. 2010;51 Suppl(Suppl):S54-66.

6D'Acquisto F. Affective immunology: where emotions and the immune response converge. Dialogues Clin Neurosci. 2017 Mar;19(1):9-19.

7Rahal, Danny, et al. "Positive and Negative Emotion Are Associated with Generalized Transcriptional Activation in Immune Cells." Psychoneuroendocrinology, vol. 153, 2023, 106103, ISSN 0306-4530.

8Segerstrom SC, Miller GE. Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychol Bull. 2004 Jul;130(4):601-30.

9Morey JN, et. al. Current Directions in Stress and Human Immune Function. Curr Opin Psychol. 2015 Oct 1;5:13-17.

10Mahindru A, Patil P, Agrawal V. Role of Physical Activity on Mental Health and Well-Being: A Review. Cureus. 2023 Jan 7;15(1):e33475.

11Nieman, D., et. al. The compelling link between physical activity and the body's defense system. J. Sport Health Sci. 2019 May; 8(3): 201-217.

12Besedovsky, L., et. al. Sleep and immune function. Pflugers Arch. 2012 Jan;463(1):121-37.

13Iddir M, et. al. Strengthening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis. Nutrients. 2020 May 27;12(6):1562.