What are Peyer’s Patches?

The Unique Location and Function of Your Many Peyer’s Patches

The lymphatic system, which is a part of your immune system, is a network of vessels, glands, organs and tissues that work together to protect your body, remove cellular waste and maintain bodily fluid levels.

Various lymphatic organs, such as Peyer’s patches, produce and release specialized white blood cells, known as lymphocytes, and other immune cells to help eliminate potentially risky material before it can cause harm to your body. The other major function of the lymphatic system is to drain extra lymph fluid – which is mostly made up of white blood cells, protein molecules and glucose – from bodily tissues and return it to the blood stream.

What are Peyer’s Patches?

Peyer’s patches are roughly egg-shaped masses of lymphatic tissue organized into follicles containing a number of key immune cells. They belong to the Gut-Associated Lymphoid Tissue (GALT), forming an important part of your immune system, and play a crucial role in monitoring the contents of your digestive tract — initiating a defense strategy when necessary.

Where are Peyer’s Patches Located?

Peyer’s patches are a series of small lymphatic nodules (similar to lymph nodes) situated in the mucus lining of your small intestine. Most people have between 30 and 40 Peyer’s patches that vary in size, shape and distribution from person to person. However, the majority of Peyer’s patches are found in the ileum region, which is the last portion of your small intestine responsible for further digestion, as well as absorbing water and nutrients from food.

Peyer’s Patches Functions

Your digestive tract is not only home to thousands of living microorganisms, including fungi and bacteria, but is also continuously being exposed to more external substances. Meanwhile, the microbes in your digestive system – collectively known as your gut microbiome – are in close contact with your immune system; and the good and bad bacteria residing in your guy influences your body’s immune response.

The main function of Peyer’s patches is to monitor the various microbes in your digestive system, surveying for any potentially harmful substances, and activating an appropriate immune response to protect your body (a function known as immunosurveillance). It does so by helping identify antigens and producing antibodies. Let’s take a closer look.

An antigen is a molecule on a substance (usually an external substance) that stimulates an immune response against that substance. An antibody is a protein produced by your immune system when it detects an antigen, marking it for destruction. Various immune cells then carry out a full-blown defensive strategy to eliminate the substance.

As mentioned above, the inside of Peyer’s patches contain a number of important immune cells, including macrophages, dendritic cells, T cells and B cells. Specialized cells known as microfold cells (M cells) line the surface of each Peyer’s patch, facing the inner tubing of your small intestine.

When M cells encounter an external substance in your digestive tract, the specialized cells absorb and transport the antigen into the Peyer’s patches across M-cell specific pores. Once in the Peyer’s patches, M cells feed the antigen to the dendritic cells and macrophages, which then present the antigen to your T cells and B cells. If the antigen is potentially harmful, your T cells and B cells will activate a strategic immune response.

How IMMUSE™ Postbiotic Interacts with the Peyer’s Patches for More Comprehensive Immune Support

Peyer’s patches are home to a rare type of dendritic cell known as plasmacytoid dendritic cell (pDC) that behaves as a leader of the immune system. Discovered in the 1990s, activated pDCs recruit, stimulate and organize an entire army of immune cells for a more complete immune response.

Remember that Peyer’s patches are located in your small intestine. Whereas probiotics deliver live bacteria to your large intestine – aiming to restore a healthy balance of good and bad bacteria in your gut microbiome – IMMUSE (LC-Plasma) is a cutting-edge postbiotic that directly activates pDCs. The majority of which are housed within the follicles of Peyer’s patches.

Orally consumed, the postbiotic travels through your digestive tract to the small intestines where M cells pick up the small particles and carry them into your Peyer’s patches. The small particles of IMMUSE™ directly activate pDCs, subsequently stimulating additional key immune cells located within your Peyer’s patches. The army of stimulated immune cells then circulate throughout your body, strengthening and boosting your immune system.

Learn more about the vital role of pDCs in immune defense, and how IMMUSE postbiotic provides more comprehensive immune support below.

Vital Role of pDCs

1University of East Anglia. "It's official -- spending time outside is good for you." ScienceDaily, 6 July 2018.
2Kuo M. How might contact with nature promote human health? Promising mechanisms and a possible central pathway. Front Psychol. 25 August 2015; 6: 1093.
3University of Illinois College of Agricultural, Consumer and Environmental Sciences. "Immune system may be pathway between nature and good health." ScienceDaily, 16 September 2015.
4Hunter M. R., et. al. Urban Nature Experiences Reduce Stress in the Context of Daily Life Based on Salivary Biomarkers. Front. Psychol. 4 April 2019; 10.
5Andersen L., et. al. Nature Exposure and Its Effects on Immune System Functioning: A Systematic Review. Int J Environ Res Public Health. 2021 Feb; 18(4): 1416.
6Li Q., et. al. Effect of phytoncide from trees on human natural killer cell function. Int J Immunopathol Pharmacol. 2009 Oct-Dec; 22(4): 951-9.
7Lvu B., et. al. Benefits of A Three-Day Bamboo Forest Therapy Session on the Psychophysiology and Immune System Responses of Male College Students. Int. J. Environ.
Res. Public Health. 2019; 16: 4991. 8Kim T., et. al. Therapeutic Potential of Volatile Terpenes and Terpenoids from Forests for Inflammatory Diseases. Int J Mol Sci. 2020 Mar; 21(6): 2187.